MT1-MMP: Endosomal delivery drives breast cancer metastasis
نویسنده
چکیده
The membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.
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عنوان ژورنال:
دوره 211 شماره
صفحات -
تاریخ انتشار 2015